19th Meeting of the French Society of Toxinology (SFET)

"Toxins and Ion Transfers"

28-29 November 2011, Pasteur Institute, Paris - France

Monday, November 28

• 8h30 - 9h00 : Coffee
• 9h00 - 9h10 : Welcome. Denis SERVENT (SFET President)

• 9h10 - 12h40 : Session Toxins and Ion Channels
  Chairman : Marie-France Martin-Eauclaire, Christian Legros Session
  

• 9h10 - 9h40 : Frank Bosmans
  (Porter Neuroscience Research Center, National Institutes of Health, Bethesda and Johns Hopkins Medical School – Physiology Department, Baltimore, USA)
  Function and pharmacology of sodium channel voltage sensors

• 9h40 - 10h00 : Marie-France Martin-Eauclaire
  (ToxCiM, Dept. Signalisation Neuronale, Centre de Recherches en Neurobiologie-Neurophysiologie de Marseille, France)
  Overview of the small Kv channels blockers from Androctonus venoms

• 10h00 – 10h20 : Sylvie Diochot
  (Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice-Sophia-Antipolis, France)
  Analgesic properties of APETx2, a sea anemone peptide inhibiting ASIC3, in inflammatory and post-operative pain models
• 10h20 – 10h40 : Jordi Molgo
  (Institut de Neurobiologie Alfred Fessard, CNRS, Gif sur Yvette, France) Pinnatoxins: an emergent family of marine phycotoxins targeting nicotinic acetylcholine receptors with high affinity
  

• 10h40 - 11h10 : Coffee break & posters

• 11h10 - 11h40 : Stefan Heinemann
  (Center for Molecular Biomedicine, University of Jena, Germany)
  Modulation of voltage-gated sodium channels with peptide toxins

• 11h40 – 12h00 : Jan Siemens
  (Max-Delbrück Center for Molecular Medicine, Berlin, Germany)
  A bivalent tarantula toxin produces inflammatory pain by targeting the outer pore domain of the capsaicin receptor TRPV1
  

• 12h00 – 12h20 : Bruno Lapied
  (Laboratoire Récepteurs et Canaux Ioniques Membranaires, Université d’Angers, France)
  Neurotoxic action of the repellent DEET occurs through positive and negative allosteric modulation of muscarinic acetylcholine receptors

• 12h30-15h00 : Lunch, Poster session

• 15h00 – 18h00 : Session Pore-Forming Toxins I
  Chairmen : Daniel Ladant, Cesare Montecuccco
  

• 15h00 – 15h30 : Vittorio Ricci
  (Department of Physiology, University of Pavia, Italy)
  VacA from Helicobacter pylori: journey and action mechanism in epithelial cells

• 15h30 – 15h50 : Joachim Rassow
  (Institut für Physiologische Chemie, Bochum, Germany)
  Targeting of Helicobacter pylori VacA to mitochondria

• 15h50 - 16h20 : Michel Popoff
  (Unité des Bactéries anaérobies et Toxines, Institut Pasteur, Paris, France)
  Clostridium perfringens epsilon toxin; a fascinating pore-forming toxin
• 16h20 – 16h40 : Ajit K. Basak
  (Department of Biological Sciences, Birkbeck College, London, UK)
  Structural Studies Reveal Novel Relationships betwee Clostridium perfringens Pore-forming Toxins

• 16h40 – 17h00 : Roland Benz
  (Rudolf-Virchow-Center, University of Würzburg, Germany)
  Influences of His-tag in the Uptake of Different Effectors Promoted by Anthrax Protective Antigen and C2II: A Possible Selective Translocation System Revealed

•  17h00 - 17h20 : Gilles Prevost
  (Physiopathologie et Médecine Translationnelle, Université Louis Pasteur, Strasbourg, France)
  General and particular inhibitions of the staphylococcal leucotoxin functions

• 17h30 - 19h00 : General Assembly of the SFET (J. Monod Amphitheatre) 

Tuesday, November 29

• 8h30 - 9h00 : Coffee

• 9h00 – 11h00 : Session Pore-Forming Toxins II
  Chairmen : Michel Popoff, Vittorio Ricci
  

• 9h00 – 9h30 : Rod Tweten
  (University of Oklahoma Sciences Center, Oklahoma City, USA)
  The Cholesterol-Dependent Cytolysins: Molecular Mechanism to Vaccine Development
• 9h30 – 9h50 : Alexandre Chenal
  (Unité de Biochimie des Interactions Macromoléculaires, Institut Pasteur, Paris, France)
  Diphtheria toxin: coupling of pore-forming and translocation activities
• 9h50 –10h10 : Cesare Montecucco
  (Dipartimento di Scienze Biomediche, Universitá di Padova, Italy)
  Tetanus and botulinum neurotoxins need to have two feet on the membrane to enter neurons
• 10h10 – 10h40 : Philippe Sansonetti
  (Unité de pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France)
  Antimicrobial peptides at mucosal surface: complex ensuring of a bacterial exclusion zone
• 10h40 – 11h00 : Gregor Anderluh
  (Department of Biology, University of Ljubljana, Slovenia)
  How pore forming toxins recognise sphingomyelin 

• 11h00 - 11h30 : Coffee break & posters 

• 11h30 – 16h20 : Session Toxins as Tools and Therapeutics
  Chairmen : Richard Lewis, Pierre Escoubas
  

• 11h30 – 12h00 : Ines Ibanez-Tallon
  (Department of Neuroscience, Max Delbrück Center for Molecular Medicine, Berlin, Germany)
  From ion channels to behavior: in vivo dissection of circuits controlling pain and addiction
• 12h00 – 12h20 : Michel Partiseti
  (Sanofi-Aventis, Vitry sur Seine, France)
  Moving away from small molecules in ion channel discovery: opportunities and challenges
  
• 12h20 – 12h40 : Holger Barth
  (University of Ulm Medical Center, Ulm, Germany)
  Tailored ß-cyclodextrin blocks membrane translocation of binary exotoxins from Clostridium botulinum and Clostridium perfringens and protects mammalian cells from intoxication

• 12h45-14h30 : Lunch, Poster session

• 14h30 – 15h00 : Richard Lewis
  (Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia)
  Ion channel toxins for drug discovery and development
• 15h00- 15h20 : Nicolas Gilles
  (Laboratoire de Toxinologie Moléculaire et Biotechnologie, CEA/iBiTecS, Saclay, France)
  G protein-coupled receptors, an unexploited family of animal toxin targets: Exploration of green mamba venom for novel ligands of adrenoceptors
• 15h20 – 15h40 : Pierre Escoubas
  (VenomeTech, Nice, France)
  Development of a parallel refolding platform for disulfide-linked peptides
• 15h40 – 16h00 : Marion Tarbe
  (UMR-6264, Laboratoire Chimie Provence, Marseille, France)
  KITOXAN®, a Venom Fraction Library to Accelerate the Identification of Anti-angiogenic Peptides
  
• 16h00 – 16h20 : Naziha Marrakchi
  (Laboratory of Venoms Toxins, Pasteur Institute of Tunis, Tunisia)
  Anti-tumoral snake venoms peptides
  

• 16h20 – 17h40 : Session Miscellaneous
  Chairwoman : Grazyna Faure
  

• 16h20 – 16h40 : Marie-Laure Pinel
  (Faculté de Pharmacie, Université de Rennes, France)
  Dual function for an overlapping RNA pair expressed by S. aureus: One encodes a membrane polypeptide and the other is a down regulator
• 16h40 – 17h00 : Frédéric Ducancel
  (Laboratoire d’Ingénierie des Anticorps pour la Santé, CEA/iBiTecS, Saclay, France)
  Interaction of engineered sarafotoxins with endothelin receptors
• 17h00 – 17h20 : Emmanuel Jover
  (INCI – UPR-CNRS 3212 , Neurotransmission et sécrétion neuroendocrine, Strasbourg, France)
  Neurotoxicity Staphylococcus aureus Leucotoxins: interaction with the Store Operated Calcium Entry Complex in central and sensory neurons
• 17h20 – 17h40 : Guillaume Blanchet
  (Laboratoire de Toxinologie Moléculaire et Biotechnologie, CEA/iBiTecS, Saclay, France)
  Aminergic toxins : When Green mamba produces GPCR tools

• 17h45 : Closure. Denis SERVENT (SFET President)